FceRI Antibodies - From William Smith

My understanding is that there are still no commercial tests, the area has been difficult for technical reasons and also for reasons of test peformance- poor specificity in immunoassays, poor correlation between immuno and functional assays. Functional assays (BAT and histamine release) remain gold standard but reproducibility is poor and difficult to commercialise.
Regards, William

Anti-FcERIa and anti-IgE

Hi Martyn,

I came across this from the Mayo Clinic: http://www.mayomedicallaboratories.com/test-catalog/print.php?unit_code=91788

It looks like the test is done by National Jewish, and they look at CD203c upregulation on donor basophils.

Has anyone here sent them serum before?

I have been testing for anti-FcERIa and anti-IgE by an in-house RIA for research. However, this has not been validated yet. 

Priscilla

Priscilla Auyeung 

PhD student
Harrison Lab
Walter and Eliza Hall Institute
1G Royal Parade, Parkville, VIC 3052, Australia
Tel: +61 3 9345 2459
Fax: +61 3 9345 2911
auyeung@wehi.edu.au

Autoantibodies to FceRI or IgE

Is anyone aware of the availability of assays for autoantibodies to FceR1a or IgE?

 

Martyn

 

Professor Martyn A French MB ChB, MD, FRCPath, FRCP, FRACP
Clinical Immunologist, Department of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine
Winthrop Professor in Clinical Immunology and Deputy Head, School of Pathology and Laboratory Medicine, University of Western Australia
Telephone: +61-8-92242899
Fax: +61-8-92242920
E-mail: martyn.french@health.wa.gov.au (hospital); martyn.french@uwa.edu.au (university)