Soluble Cytokine Measurement - From Martyn French

Thanks to Martyn for his further insights on soluble CD163 and its utility:

"There are data showing that sCD163 is good marker of monocyte activation in HIV patients,

Soluble Cytokine Measurement - From Andrew Whyte

Any help on this query, from Andrew Whyte, is welcomed:

"I have an interesting patient in whom I want to measure soluble CD163
in addition to soluble CD25

Desmoglein Antibodies in a case of Resistant Pemphigus - From Stephen Adelstein

Attached* may help – published last week

Desmoglein Antibodies in a case of Resistant Pemphigus - From David Fulcher

As Julian mentioned, we are doing dsg-1 and 3 antibodies quantitatively by ELISA. We are about to publish a series of 55 cases assessed at enrolment, then followed sequentially 

Desmoglein Antibodies in a case of Resistant Pemphigus - From Daman Langguth

More pithy pearls from Daman:
"[Westmead]...And yes titres are useful.

Failure in pemphigus with ritux unusual when Bcells depleted."

Desmoglein Antibodies in a case of Resistant Pemphigus - From Julian Bosco

Thanks to Julian Bosco for reminding of David Fulcher's interest in this domain -- David, Any comments?

Desmoglein Antibodies in a case of Resistant Pemphigus - From Kerri Prain

Pathology Queensland (RBH) is performing DSG 1/3 testing on Transfected cells.

Regards

Kerri

Desmoglein Antibodies in a case of Resistant Pemphigus - From Chris Bundell

Thanks to Chris for her input on this question:

"PathWest has the Skin Mosaic put out by Euroimmun.  It includes the desmoglein 1 and 3 and is reported as detected or not detected."

Desmoglein Antibodies in a case of Resistant Pemphigus - From Peter Bourke

Hi Glenn,

We have a 39yo Indigenous female patient with pemphigus (for >10 years) which was resistant to routine immunosuppression and so we tried rituximab.

Circulating CD19 B cells are undetectable still, now >4 months after rituximab but there is no significant improvement in the lesions