As you know the GAD antibody seen in Stiff-Person Syndrome is picked up on islet cell substrate (see picture below), even though this is usually used to detect the anti-GAD65 antibodies seen in DM Type I
Is anyone in our group aware of potential utility &/or availability of more specific antibody test for the GAD67 antigen which is more associated with the autoimmune condition affecting brain? Or are they so similar structurally that a cross-reactive antibody is adequate?
Any input welcomed
Regards
Glenn
Anti-GAD IIF Monkey Cerebellum:
Pancreas GAD Staining:
