Both EBV and VZV have very differing life cycles to HSV1 and 2. EBV and VZV both replicate expressing intracellular levels of viral transcripts during clinical quiescence. During quiescence HSV and 2 do not express viral transcripts, though curiously, HSV 1 and 2 have asymptomatic viral shedding though this does not occur in EBV and VZV.
All (except VZV I think) have IL-10 homologues (as does CMV) thought used to prevent the harbouring site being destroyed, though on VZV this perhaps is not useful.
Surely his lymphopenia is key.
I have a man in mid 50's presented with necrotizing HSV2 (genital) and subsequently has had 3 cutaneous melanoma, and 2 KS. He isn't of the genetic background for KS, and he has neg HIV, but he does have a CD4 count that floats 200-350.
I think like in HIV, some people can get CD4 depletion for specific viruses (perhaps under direction of some malfunctioning CD4 memory maintenance).
