Thanks to John Quin for more input on discussion about the severity of ACEI-related angioedema:
"Dear All- Liverpool has about one to 2 patients a month admitted for   ACEI induced angioedema.  About half of these are severe enough to   require ICU and one patient was in ICU for a week.  His treatment was   complicated by the use of sotalol, a long acting beta blocker.  We have   used icatibant with success but it still takes up to 2-3 hours to work - John Quin"
